The best cattle fly pour-on depends on which pests you need to control, whether you want an insect growth regulator, and how many animals you treat. Clean-Up II and Gardatis are best for buyers seeking fly and lice control with an IGR, while CyLence offers a ready-to-use option for face flies, horn flies, and lice. Permectrin CDS covers additional pests, and Durvet is a broad-spectrum choice. Always follow the product label for application directions, approved animals, and precautions.
| Product | Best For | Notable Feature |
|---|---|---|
| Clean-Up II | Fly and lice control with an IGR | Ready to use; listed for beef and dairy cattle |
| CyLence | Targeting face flies, horn flies, and lice | No mixing required |
| Gardatis | Fly and lice control with two active ingredients | Contains an insecticide and an IGR |
| Permectrin CDS | Control of flies, lice, ticks, and mosquitoes | Animal and premises applications |
| Durvet Fly Synergized | Broad-spectrum insect control | Ready-to-use, oil-based formula |
Clean-Up II Pour-On

Best for: Cattle owners who want a ready-to-use pour-on with an insect growth regulator (IGR) for flies and lice. Elanco lists this product for beef and dairy cattle, including lactating cattle, as well as horses.
The product controls several listed flies, including horn, house, stable, black, deer, and horse flies. It also controls biting and sucking lice and kills louse eggs before they hatch. The ready-to-use suspension does not require mixing. Its listed features state there is no pre-slaughter or milk withholding period.
Why it stands out: It combines a broad listed fly range with adult lice and egg control. Limitation: The product’s listed pest range does not include ticks or mosquitoes, so choose another option if those are a priority.
CyLence Pour-On

Best for: Buyers seeking a straightforward treatment for face flies, horn flies, and lice on beef or dairy cattle, including lactating cattle. The ready-to-use formula requires no mixing, and the listed features say only a small amount is needed per treatment.
CyLence is described for use at any time of year and on cattle of all ages and sizes. That makes it a practical option when the target pests match its listed coverage and a simple application format matters.
Why it stands out: Its stated uses are specific and easy to compare against common fly and lice concerns. Limitation: The provided product information does not list control of stable flies, ticks, or mosquitoes, so check the label if those pests are part of the problem.
Atticus Gardatis Pour-On

Best for: Cattle and horse owners looking for fly and lice control in a formula with both an insecticide and an IGR. The listed active ingredients are 5.0% permethrin and 3.0% diflubenzuron.
Gardatis is described for use on beef cattle, dairy cattle—including lactating cattle—calves, and mature horses. Its listed target pests include sucking and chewing lice, cattle ticks, and several flies, such as horn, house, stable, horse, black, and deer flies. The ready-to-use formula is applied topically; the product information also describes wipe-on use for horses and foals.
Why it stands out: It combines a wide listed pest range with an IGR and gives application options for some horses. Limitation: The full use directions and pest list should be checked on the label before treating animals.
Permectrin CDS Pour-On

Best for: Livestock owners who want a product listing control of flies, lice, ticks, and mosquitoes. The provided features name horn flies, face flies, stable flies, lice, ticks, and mosquitoes.
The product is listed for direct application to beef and dairy cattle, including lactating cattle, as well as sheep, lambs, horses, and foals. It is also described for use on premises. The synergized insecticide is ready to use without dilution, except when used for a back rubber application.
Why it stands out: Its listed target pests and species extend beyond cattle flies alone. Limitation: Back-rubber use is an exception to the no-dilution direction; follow the label for that method and all other applications.
Durvet Fly Synergized Pour-On

Best for: Buyers comparing ready-to-use products described as providing broad-spectrum insect control. The listed features identify a synergized formula and an oil-based application intended for use any time of year.
Why it stands out: The ready-to-use format avoids a mixing step, while the broad-spectrum description may suit buyers comparing options for general insect control. Limitation: The provided features do not specify particular target pests or approved animal classes. Check the complete label to confirm that the product is appropriate for your cattle and the insects you need to control.
Buying Guide
Which flies and other pests need control?
Start by identifying the pests affecting your herd. Product coverage varies: CyLence lists face flies and horn flies, while Clean-Up II lists several additional fly types and lice. Gardatis and Permectrin CDS include ticks in their stated pest coverage. Match the label’s exact pest list to your needs rather than relying on general terms such as “broad spectrum.”
Do you want an IGR?
An insect growth regulator is included in Clean-Up II and Gardatis, according to their product information. Clean-Up II is described as controlling lice and killing louse eggs before they hatch. Gardatis lists an insecticide and an IGR in its dual-active formula. Compare the labeled claims and directions when deciding whether this feature fits your lice-control plan.
Are you treating dairy cattle or other species?
Check the approved animal classes before choosing a product. The listed information identifies several options for beef and dairy cattle, including lactating cattle, but product directions are not interchangeable. Permectrin CDS and Gardatis also list additional species. Use only as directed on the label for each animal type.
Does the application format fit your routine?
Ready-to-use products can avoid mixing, but application directions still differ. CyLence and Clean-Up II are described as ready to use. Permectrin CDS is also ready to use, with an exception for back-rubber application. Review the label for dosage, application site, treatment timing, and any handling precautions.
Frequently Asked Questions
What is a cattle fly pour-on?
It is a topical insecticide applied to cattle according to its label directions. The pests controlled and approved animal classes depend on the specific product.
Which options list lice control?
Clean-Up II, CyLence, Gardatis, and Permectrin CDS list lice control in the supplied product information. Compare their other listed pests and animal-use directions before selecting one.
Can I use a pour-on on lactating dairy cattle?
Some products in this article are listed for dairy cattle, including lactating cattle. Confirm that wording and all milk-use directions on the product label before application.
Do all pour-on products need to be diluted?
No. Several products are described as ready to use. Permectrin CDS is an exception for back-rubber application, so follow the label’s directions for the application method.
Should I choose a product based only on its fly coverage?
No. Also compare lice or tick coverage, approved animal classes, application directions, and any milk or slaughter restrictions stated on the label.